Lesion of the centromedian thalamic nucleus in MPTP‐treated monkeys
Identifieur interne : 002789 ( Main/Exploration ); précédent : 002788; suivant : 002790Lesion of the centromedian thalamic nucleus in MPTP‐treated monkeys
Auteurs : Jose L. Lanciego [Espagne] ; Maria C. Rodríguez-Oroz [Espagne] ; Francisco J. Blesa [Espagne] ; Lydia Alvarez-Erviti [Espagne] ; Jorge Guridi [Espagne] ; Pedro Barroso-Chinea [Espagne] ; Yoland Smith [États-Unis] ; Jose A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animal, Animals, Dyskinesia, Drug-Induced (diagnosis), Functional Laterality (drug effects), Intralaminar Thalamic Nuclei (drug effects), Intralaminar Thalamic Nuclei (pathology), Kainic Acid (toxicity), Kainic acid, Levodopa (adverse effects), Levodopa (therapeutic use), MPTP monkey model, Macaca fascicularis, Male, Models, Monkey, Nervous system diseases, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (physiopathology), Stereotaxic Techniques, Treatment, intralaminar thalamic nuclei, kainic acid lesion.
- MESH :
- chemical , adverse effects : Levodopa.
- chemical , therapeutic use : Levodopa.
- chemical , toxicity : Kainic Acid.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemically induced : Parkinsonian Disorders.
- diagnosis : Dyskinesia, Drug-Induced.
- drug effects : Functional Laterality, Intralaminar Thalamic Nuclei.
- drug therapy : Parkinsonian Disorders.
- pathology : Intralaminar Thalamic Nuclei.
- physiopathology : Parkinsonian Disorders.
- Animals, Macaca fascicularis, Male, Stereotaxic Techniques.
Abstract
The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6‐hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate‐induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP‐treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short‐lasting, and mild change in the parkinsonian motor scale but no effect against levodopa‐induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa‐induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/565E353B929FBAA783CEA26593099201166DAEB2/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413905
DOI: 10.1002/mds.21906
Affiliations:
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Lanciego</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea><wicri:noRegion>University of Navarra</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodríguez-Oroz">Maria C. Rodríguez-Oroz</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea><wicri:noRegion>University of Navarra</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Blesa, Francisco J" sort="Blesa, Francisco J" uniqKey="Blesa F" first="Francisco J." last="Blesa">Francisco J. 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Obeso</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurosciences Division, CIMA, Pamplona, University of Navarra</wicri:regionArea><wicri:noRegion>University of Navarra</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-15">2008-04-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="708">708</biblScope><biblScope unit="page" to="715">715</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">565E353B929FBAA783CEA26593099201166DAEB2</idno><idno type="DOI">10.1002/mds.21906</idno><idno type="ArticleID">MDS21906</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animal</term><term>Animals</term><term>Dyskinesia, Drug-Induced (diagnosis)</term><term>Functional Laterality (drug effects)</term><term>Intralaminar Thalamic Nuclei (drug effects)</term><term>Intralaminar Thalamic Nuclei (pathology)</term><term>Kainic Acid (toxicity)</term><term>Kainic acid</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>MPTP monkey model</term><term>Macaca fascicularis</term><term>Male</term><term>Models</term><term>Monkey</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (chemically induced)</term><term>Parkinsonian Disorders (drug therapy)</term><term>Parkinsonian Disorders (physiopathology)</term><term>Stereotaxic Techniques</term><term>Treatment</term><term>intralaminar thalamic nuclei</term><term>kainic acid lesion</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Kainic Acid</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Functional Laterality</term><term>Intralaminar Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Intralaminar Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Macaca fascicularis</term><term>Male</term><term>Stereotaxic Techniques</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Acide kaïnique</term><term>Animal</term><term>Maladie de Parkinson</term><term>Modèle</term><term>Pathologie du système nerveux</term><term>Singe</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6‐hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate‐induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP‐treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short‐lasting, and mild change in the parkinsonian motor scale but no effect against levodopa‐induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa‐induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Espagne"><noRegion><name sortKey="Lanciego, Jose L" sort="Lanciego, Jose L" uniqKey="Lanciego J" first="Jose L." last="Lanciego">Jose L. Lanciego</name></noRegion><name sortKey="Alvarez Rviti, Lydia" sort="Alvarez Rviti, Lydia" uniqKey="Alvarez Rviti L" first="Lydia" last="Alvarez-Erviti">Lydia Alvarez-Erviti</name><name sortKey="Alvarez Rviti, Lydia" sort="Alvarez Rviti, Lydia" uniqKey="Alvarez Rviti L" first="Lydia" last="Alvarez-Erviti">Lydia Alvarez-Erviti</name><name sortKey="Barroso Hinea, Pedro" sort="Barroso Hinea, Pedro" uniqKey="Barroso Hinea P" first="Pedro" last="Barroso-Chinea">Pedro Barroso-Chinea</name><name sortKey="Barroso Hinea, Pedro" sort="Barroso Hinea, Pedro" uniqKey="Barroso Hinea P" first="Pedro" last="Barroso-Chinea">Pedro Barroso-Chinea</name><name sortKey="Blesa, Francisco J" sort="Blesa, Francisco J" uniqKey="Blesa F" first="Francisco J." last="Blesa">Francisco J. Blesa</name><name sortKey="Blesa, Francisco J" sort="Blesa, Francisco J" uniqKey="Blesa F" first="Francisco J." last="Blesa">Francisco J. Blesa</name><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name><name sortKey="Lanciego, Jose L" sort="Lanciego, Jose L" uniqKey="Lanciego J" first="Jose L." last="Lanciego">Jose L. Lanciego</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodríguez-Oroz">Maria C. Rodríguez-Oroz</name><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodríguez-Oroz">Maria C. Rodríguez-Oroz</name><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodríguez-Oroz">Maria C. Rodríguez-Oroz</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name></region><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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